WEEK THREE
| England v Tonga Twickenham Stadium, London Saturday, 6 November, 2021 | Referee: Craig Evans (WRU) Assistant Referee 1: Adam Jones (WRU) Assistant Referee 2: Andrea Piardi (FIR) TMO: Ben Whitehouse (WRU) |
| Wales v South Africa Principality Stadium, Cardiff Saturday, 6 November, 2021 | Referee: Paul Williams (NZR) Assistant Referee 1: Andrew Brace (IRFU) Assistant Referee 2: James Doleman (NZR) TMO: Olly Hodges (IRFU) |
| Ireland v Japan Aviva Stadium, Dublin Saturday, 6 November, 2021 | Referee: Nika Amashukeli (GRU) Assistant Referee 1: Damon Murphy (RA) Assistant Referee 2: Pierre Brousset (FFR) TMO: Eric Gauzins (FFR) |
| France v Argentina Stade de France, Paris Saturday, 6 November, 2021 | Referee: Ben O’Keeffe (NZR) Assistant Referee 1: Luke Pearce (RFU) Assistant Referee 2: Christophe Ridley (RFU) TMO: Brendon Pickerill (NZR) |
| Italy v New Zealand Stadio Olimpico, Rome Saturday, 6 November, 2021 | Referee: Karl Dickson (RFU) Assistant Referee 1: Mike Adamson (SRU) Assistant Referee 2: Sam Grove-White (SRU) TMO: Tom Foley (RFU) |
| Spain v Fiji Estadio Nacional Universidad Complutense, Madrid Saturday, 6 November, 2021 | Referee: Jaco Peyper (SARU) Assistant Referee 1: Ludovic Cayre (FFR) Assistant Referee 2: Chris Busby (IRFU) TMO: Alan Falzone (FIR) |
| Romania v Uruguay Stadionul National de Rugby Arcul de Triumf, Bucharest Saturday, 6 November, 2021 | Referee: Angus Gardner (RA) Assistant Referee 1: Nic Berry (RA) Assistant Referee 2: Gianluca Gnecchi (FIR) TMO: Brett Cronan (RA) |
| Portugal v Canada CAR Rugby do Jamor, Lisbon Saturday, 6 November, 2021 | Referee: Frank Murphy (IRFU) Assistant Referee 1: Ben Blain (SRU) Assistant Referee 2: Adam Leal (RFU) TMO: N/A |
| Scotland v Australia BT Murrayfield, Edinburgh Sunday, 7 November, 2021 | Referee: Romain Poite (FFR) Assistant Referee 1: Matthew Carley (RFU) Assistant Referee 2: AJ Jacobs (SARU) TMO: Marius Jonker (SARU) |
