England travel to Murraryfield in Edinburgh on Saturday (KO 4:45pm, live on BBC) after opening the tournament with a loss to France.
Both Manu Tuilagi and Anthony Watson will return to their clubs to continue their rehabilitation.
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England head to Murrayfield looking for their first win in the Scottish capital since 2016.
Forwards
Luke Cowan-Dickie (Exeter Chiefs)
Tom Curry (Sale Sharks)
Ben Earl (Saracens)
Ellis Genge (Leicester Tigers)
Jamie George (Saracens)
Maro Itoje (Saracens)
George Kruis (Saracens)
Joe Launchbury (Wasps)
Courtney Lawes (Northampton Saints)
Lewis Ludlam (Northampton Saints)
Joe Marler (Harlequins)
Kyle Sinckler (Harlequins)
Will Stuart (Bath Rugby)
Sam Underhill (Bath Rugby)
Mako Vunipola (Saracens)
Backs
Elliot Daly (Saracens)
Ollie Devoto (Exeter Chiefs)
Owen Farrell (Saracens
George Ford (Leicester Tigers)
George Furbank (Northampton Saints)
Willi Heinz (Gloucester Rugby)
Jonathan Joseph (Bath Rugby)
Jonny May (Leicester Tigers)
Ollie Thorley (Gloucester Rugby)
Ben Youngs (Leicester Tigers)