Scotland flanker Hamish Watson has returned a positive Covid test and will not play in the Guinness Six Nations match against France on Saturday 26 February.
Edinburgh back row Nick Haining moves into the starting XV and will play on the blindside, with Rory Darge moving to the openside flanker position.
Saracens’ Andy Christie comes into the matchday 23 and is in line to make his Scotland debut if called on from the replacements.
Two members of the Scotland backroom team have also tested positive for Covid and will isolate as per Scottish Government guidelines.
Scotland team to face France in the 2022 Guinness Six Nations at BT Murrayfield live on BBC One, Saturday, 26 February – kick-off 2.15pm.
15. Stuart Hogg – Exeter Chiefs – (Captain) – 90 caps
14. Darcy Graham – Edinburgh Rugby – 24 caps
13. Chris Harris – Gloucester Rugby – 33 caps
12. Sione Tuipulotu – Glasgow Warriors – 3 caps
11. Duhan van der Merwe – Worcester Warriors – 15 caps
10. Finn Russell – Racing 92 – (Vice-Captain) – 60 caps
9. Ali Price – Glasgow Warriors – 48 caps
1. Pierre Schoeman – Edinburgh Rugby – 6 caps
2. Stuart McInally – Edinburgh Rugby – 45 caps
3. Zander Fagerson – Glasgow Warriors – 44 caps
4. Sam Skinner – Exeter Chiefs – 17 caps
5. Grant Gilchrist – Edinburgh Rugby – (Vice-Captain) – 50 caps
6. Nick Haining – Edinburgh Rugby – 10 caps
7. Rory Darge – Glasgow Warriors – 1 cap
8. Magnus Bradbury – Edinburgh Rugby – 16 caps
Replacements
16. George Turner – Glasgow Warriors – 22 caps
17. Oli Kebble – Glasgow Warriors – 11 caps
18. WP Nel – Edinburgh Rugby – 45 caps
19. Jamie Hodgson – Edinburgh Rugby – 3 caps
20. Andy Christie – Saracens – uncapped
21. Ben White – London Irish – 2 caps
22. Blair Kinghorn – Edinburgh Rugby – 29 caps
23. Mark Bennett – Edinburgh Rugby – 22 caps