WEEK TWO:
| Spain v Tonga Stadium Ciudad de Malaga, Malaga Saturday, 5 November, 2022 | Referee: Damon Murphy (RA) Assistant Referee 1: Ludovic Cayre (FFR) Assistant Referee 2: Adrien Marbot (FFR) |
| Scotland v Fiji Murrayfield, Edinburgh Saturday, 5 November, 2022 | Referee: Nic Berry (RA) Assistant Referee 1: James Doleman (NZR) Assistant Referee 2: Adam Jones (WRU) TMO: Brett Cronan (RA) |
| Italy v Samoa Stadio Plebiscito, Padova Saturday, 5 November, 2022 | Referee: Christophe Ridley (RFU) Assistant Referee 1: Luke Pearce (RFU) Assistant Referee 2: Katlil Harrison (USA) TMO: Brendon Pickerill (NZR) |
| Wales v New Zealand Principality Stadium, Cardiff Saturday, 5 November, 2022 | Referee: Wayne Barnes (RFU) Assistant Referee 1: Karl Dickson (RFU) Assistant Referee 2: Gianluca Gnecchi (FIR) TMO: Brian MacNeice (IRFU) |
| Ireland v South Africa Aviva Stadium, Dublin Saturday, 5 November, 2022 | Referee: Nika Amashukeli (IRFU) Assistant Referee 1: Mathieu Raynal (FFR) Assistant Referee 2: Andrea Piardi (FIR) TMO: Stuart Terheege (RFU) |
| France v Australia Stade de France, Paris Saturday, 5 November, 2022 | Referee: Jaco Peyper (SARU) Assistant Referee 1: Ben O’Keeffe (NZR) Assistant Referee 2: Craig Evans (WRU) TMO: Tom Foley (RFU) |
| Romania v Chile Stadionul National Arcul de Triumf, Bucharest Saturday, 5 November, 2022 | Referee: Mike Adamson (SRU) Assistant Referee 1: Sam Grove-White (SRU) Assistant Referee 2: Ben Blain (SRU) TMO: Marius van der Westhuizen (SARU) |
| Georgia v Uruguay Dinamo Arena, Tbilisi, Georgia Sunday, 6 November, 2022 | Referee: Paul Williams (NZR) Assistant Referee 1: Anthony Woodthorpe (RFU) Assistant Referee 2: Talal Chaudhry (RC) TMO: Chris Hart (NZR) |
| England v Argentina Twickenham, London Sunday, 6 November, 2022 | Referee: Andrew Brace (IRFU) Assistant Referee 1: Frank Murphy (IRFU) Assistant Referee 2: Pierre Brousset (FFR) TMO: Marius Jonker (SARU) |