Centre Ben Te’o has been ruled out of England’s Six Nations match with Ireland on Saturday with a side strain.
The Worcester player picked up the injury in training in Portugal this week and will not travel to Dublin.
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Meanwhile, Wasps flanker Brad Shields will also miss the game at the Aviva Stadium, as will Bath wing Joe Cokanasiga.
Te’o’s absence means Manu Tuilagi is in strong contention to make his first England start since 2014.
The England management hope Te’o will be available for the France game on the second weekend of the Championship, but his absence on Saturday leaves a physical void in the midfield, which Tuilagi is set to fill.
Forwards: Luke Cowan-Dickie (Exeter Chiefs), Tom Curry (Sale Sharks), Ellis Genge (Leicester Tigers), Jamie George (Saracens), Nathan Hughes (Wasps), Maro Itoje (Saracens), George Kruis (Saracens), Joe Launchbury (Wasps), Courtney Lawes (Northampton Saints), Kyle Sinckler (Harlequins), Billy Vunipola (Saracens), Mako Vunipola (Saracens), Harry Williams (Exeter Chiefs), Mark Wilson (Newcastle Falcons)
Backs: Chris Ashton (Sale Sharks), Mike Brown (Harlequins), Elliot Daly (Wasps), Owen Farrell (Saracens) captain, George Ford (Leicester Tigers), Jonny May (Leicester Tigers), Jack Nowell (Exeter Chiefs), Dan Robson (Wasps), Henry Slade (Exeter Chiefs), Manu Tuilagi (Leicester Tigers), Ben Youngs (Leicester Tigers)