England will be without loosehead prop Mako Vunipola for their entire November international campaign after he was ruled out for eight weeks.
Saracens confirmed his injury timescale on Wednesday which means he joins his brother and number eight Billy in missing the Test fixtures.
The Premiership club also revealed that another of their international stars, Nick Isiekwe, will miss six weeks to cap a tough week for Sarries.
Prop Vunipola has a calf tear while second-row Isiekwe is out with an ankle sprain, with both injuries picked up in the match against Glasgow.