Ireland stars James Ryan and Garry Ringrose have been ruled out of Ireland’s final Six Nations match against England.
Vice-captain Ryan was forced off for a head injury assessment during Sunday’s 27-24 win over Scotland.
The six-day turnaround means the second-row could not complete the return-to-play protocols in time.
Meanwhile, outside-centre sustained an ankle injury in that game.
However, flanker Peter O’Mahony will return from a three-match ban for the visit of Eddie Jones’s men.
reland Squad Round 5 – 2021 Guinness Six Nations Championships.
Bundee Aki (Connacht/Galwegians) 30 caps
Billy Burns (Ulster) 6 caps
Ross Byrne (Leinster/UCD) 12 caps
Craig Casey (Munster/Shannon) 1 cap
Andrew Conway (Munster/Garryowen) 24 caps
Keith Earls (Munster/Young Munster) 92 caps
Chris Farrell (Munster/Young Munster) 14 caps
Jamison Gibson Park (Leinster) 9 caps
Robbie Henshaw (Leinster/Buccaneers) 51 caps
Hugo Keenan (Leinster/UCD) 10 caps
Jordan Larmour (Leinster/St Mary’s College) 27 caps
James Lowe (Leinster) 6 caps
Stuart McCloskey (Ulster/Bangor) 4 caps
Conor Murray (Munster/Garryowen) 88 caps
Jonathan Sexton (Leinster/St Mary’s College) 98 caps
Jacob Stockdale (Ulster/Lurgan) 33 caps
Ryan Baird (Leinster/Dublin University) 2 caps
Finlay Bealham (Connacht/Buccaneers) 14 caps
Tadhg Beirne (Munster/Lansdowne) 21 caps
Ed Byrne (Leinster/UCD) 4 caps
Jack Conan (Leinster/Old Belvedere) 19 caps
Will Connors (Leinster/UCD) 9 caps
Ultan Dillane (Connacht/Corinthians) 18 caps
Tadhg Furlong (Leinster/Clontarf) 48 caps
Cian Healy (Leinster/Clontarf) 108 caps
Dave Heffernan (Connacht/Buccaneers) 5 caps
Iain Henderson (Ulster/Academy) 62 caps
Rob Herring (Ulster/Ballynahinch) 20 caps
Ronan Kelleher (Leinster/Lansdowne) 10 caps
Dave Kilcoyne (Munster/UL Bohemians) 42 caps
Peter O’Mahony (Munster/Cork Constitution) 74 caps
Andrew Porter (Leinster/UCD) 35 caps
Rhys Ruddock (Leinster/St Mary’s College) 27 caps
CJ Stander (Munster/Shannon) 50 caps
Josh van der Flier (Leinster/UCD) 30 caps
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- CONOR MURRAY (Munster) – £565,000
- JOHNNY SEXTON (Leinster) – £536,000
- TADHG FURLONG (Leinster) – £530,000