Wyn Jones has suffered a calf injury in training ruling him out of the test against Argentina on Saturday and the remainder of the summer tour.
Jones will return to the Scarlets for further diagnosis and prognosis.
Rob Evans, who was due to start on the bench on Saturday comes into the starting XV with Nicky Smith added to the replacements.
WALES TEAM TO FACE ARGENTINA (San Juan, Saturday June 9, KO 16.40 local)
15. Hallam Amos (16 Caps)
14. Josh Adams (2 Caps)
13. Scott Williams (55 Caps)
12. Hadleigh Parkes (7 Caps)
11. George North (74 Caps)
10. Rhys Patchell (8 Caps)
9. Gareth Davies (32 Caps)
1. Rob Evans (25 Caps)
2. Elliot Dee (8 Caps)
3. Dillon Lewis (3 Caps)
4. Adam Beard (2 Caps)
5. Cory Hill (16 Caps) (CAPTAIN)
6. Seb Davies (5 Caps)
7. James Davies (1 Cap)
8. Ross Moriarty (21 Caps)
Replacements:
16. Ryan Elias (3 Caps)
17. Nicky Smith
18. Tomas Francis (31 Caps)
19. Josh Turnbull (8 Caps)
20. Aaron Wainwright (*Uncapped)
21. Aled Davies (9 Caps)
22. Gareth Anscombe (16 Caps)
23. Owen Watkin (5 Caps)