Saracens prop Mako Vunipola has been ruled out for the rest of the season and will miss the remainder of his club’s Premiership campaign.
The England prop sustained the injury in Saracens’ European Champions Cup win over Leinster last Saturday.
Vunipola’s hamstring injury requires surgery and will take a minimum of three months to recover.
England face fixtures against Wales on 11 and 17 August, before playing Ireland (24 August) and Italy (6 September).