#2. Charlie Ewels
Lucky to be in the squad after a poor Six Nations, Ewels suffered a serious knee injury that could see him ruled out until the end of the year. The emergence of Ollie Chessum and the reemergence of Nick Isiekwe probably means the Bath man has won his last cap for England.
Potential replacements: Joe Launchbury (Wasps), Ollie Chessum (Leicester Tigers), Nick Isiekwe (Saracens)