Lock Jake Ball and flanker Justin Tipuric have been ruled out of Wales’ final autumn Test against South Africa on Saturday by injury.
The second-rowwill undergo shoulder surgery after coming off in the 25 November defeat by New Zealand.
Meanwhile, open-side Tipuric has a thigh injury and has returned to Ospreys.
Scrum-half Rhys Webb came off after a head blow against the All Blacks and must pass concussion protocols to face the Springboks.