Steve Borthwick is set to shake up his England team against Japan, with Henry Pollock, Max Ojomoh and Will Joseph all reportedly handed starting roles.
According to The Times, the trio are expected to start Saturday's Nations Championship clash at Allianz Stadium.
England head into the contest following their impressive 45-22 victory over Australia.
However, injuries have forced Borthwick into several changes ahead of next week's showdown with New Zealand.
Henry Pollock handed starting role
Pollock is reportedly set to start at number eight after scoring twice against Australia.
The Northampton Saints youngster finished that match on the wing but is expected to return to the back row for his second Test start.
Gloucester's Will Joseph is also set for his first England start, more than four years after making his international debut.
The 24-year-old has reportedly moved ahead of Joe Marchant in the selection race.
Henry Pollock is reportedly set to start at number eight for England against Japan.
Max Ojomoh wins midfield battle
Bath centre Max Ojomoh is expected to replace the injured Seb Atkinson at inside centre.
The 25-year-old impressed during England A's 59-24 victory over Argentina XV last Friday.
Borthwick had been weighing up Ojomoh and Fraser Dingwall, but the Bath man has reportedly won that battle.
He could now partner Henry Slade in midfield.
Predicted England XV vs Japan
RUCK's predicted line-up, incorporating the three starters reported by The Times and other selection reports.
15. Marcus Smith
14. Tommy Freeman
13. Henry Slade
12. Max Ojomoh
11. Will Joseph
10. Fin Smith
9. Jack van Poortvliet
1. Fin Baxter
2. Jamie George
3. Joe Heyes
4. Maro Itoje (c]
5. George Martin
6. Alex Coles
7. Ben Earl
8. Henry Pollock
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