Jack Willis, a 26-year-old openside flanker, will miss the rest of England's Six Nations training camp and return to his club, Toulouse, on Thursday.
This is a further setback for new coach Steve Borthwick, who has already lost several players to injury.
Willis joined Toulouse in November, but was allowed to participate in the camp due to regulations for players based outside of England being relaxed due Wasps and Worcester's demise.
However, as the official international Test window has not yet begun, Willis's involvement must end on Thursday.
Despite this, he is still in contention to start against Scotland, making his departure from the camp unwelcome for Borthwick.
RANKED: Which 2023 Six Nations Team Has the Most Foreign-Born Players?
The 2023 Six Nations Championship is the 24th edition of the competition since expanding to include Italy in 2000.
It was originally conceived as the Home Nations Championship and first contested by England, Ireland, Scotland, and Wales in 1883. France joined in 1910 to create the Five Nations Championship.
There were 59 foreign-born players in the 2021 Six Nations. The player rosters for the 2022 competition number totalled of 73 foreign-born players
#6. England (4/36) - Up by two
On 16 January 2023, Borthwick named a 36-player England squad for the 2023 Six Nations Championship
Bevan Rodd (Scotland)
Mako Vunipola (New Zealand)
Marcus Smith (Phillipines)
Manu Tuilagi (Samoa)
Manu Tuilagi of England during the Autumn Nations Match between England and Tonga at Twickenham Stoop on 6 November 2021. Photo: Tom Sandberg/PPAUK
#5. France (5/42) - Up by one
On 17 January 2023, Galthié named a 42-man squad for the 2023 Six Nations Championship.
Uini Atonio (New Zealand)
Dany Priso (Cameroon)
Paul Willemse (South Africa)
Émilien Gailleton (England)
Yoram Moefana (Wallis and Futuna)
#4. Italy (6/34) - Down by three
On 10th January Kieran Crowley announced a 34-man squad for the Italy's opening two matches of the matches against .
(5 Feb) and England (12 Feb)
Marco Manfredi (Germany)
Sebastian Negri (Zimbabwe)
Jake Polledri (England)
Stephen Varney (Wales)
Ignacio Brex (Argentina)
Ange Capuozzo (France)
#2. Ireland (6/37)
Finlay Bealham (New Zealand)
Rob Herring (South Africa)
Joe McCarthy (USA)
Bundee Aki (New Zealand)
Jamison Gibson-Park (New Zealand)
James Lowe (New Zealand)
Bundee Aki of Ireland watching the on going scrum during the Six Nations Championship match between England and Ireland at Twickenham Stadium, Twickenham, London on the 12th March 2022 - PHOTO: George Tewkesbury/PPAUK
#2. Wales (7/37) - Down by five
On 17 January 2023, Wales coach Warren Gatland named a 37-man squad for the Six Nations.
Bradley Roberts (South Africa)
Tomas Francis (Wales)
Taulupe Faletau (Tonga)
Taulupe Faletau during the Gallagher Premiership Rugby Match between Bath Rugby and Saracens at the Recreation Ground on 17 Oct. Photo: Steve Haag/PPAUK
Christ Tshiunza (Democratic Republic of the Congo)
George North (England)
Nick Tompkins (England)
Alex Cuthbert (England)
#1. Scotland (21/40) - Up by two
On 17 January 2023, Scotland coach Gregor Townsend named a 40-player squad for the 2023 Six Nations Championship.
Ewan Ashman (Canada)
Simon Berghan (New Zealand)
WP Nel (South Africa)
Pierre Schoeman (South Africa)
Javan Sebastian (Wales)
Cameron Henderson (Hong Kong)
Sam Skinner (England)
Josh Bayliss (England)
Andy Christie (England)
Jack Dempsey (Australia)
Hamish Watson (England)
Final whistle celebrations for Scott Steele of Scotland and Hamish Watson of Scotland during the Six Nations Championship, 127th Calcutta Cup match between England and Scotland at Twickenham Stadium, Twickenham, London on January 6 2021. - PHOTO: Phil Mingo/PPAUK
Ali Price (England)
Ben White (England)
Ben Healy (Ireland)
Chris Harris (England)
Cameron Redpath (France)
Sione Tuipulotu (Australia)
Sean Maitland (New Zealand)
Ruaridh McConnochie (England)
Kyle Steyn (South Africa)
Duhan van der Merwe (South Africa)
