Joe Launchbury and Joe Marler out of England’s Six Nations squad.
Second-row Launchbury has suffered a leg injury while Marler has withdrawn for personal reasons.
Head coach Eddie Jones has called up Charlie Ewels and Tom West to join the tournament squad ahead of opener against Scotland on February 6.
“Always grateful for the opportunity so not an easy decision, but want to do right by my family in these crazy times and won’t be meeting up with the squad for this tournament,” wrote Marler.
“Look forward to watching the team rip in. Go well.”
Elliot Daly (Saracens, 47 caps)
Owen Farrell (Saracens, 88 caps)
George Ford (Leicester Tigers, 72 caps)
Ollie Lawrence (Worcester Warriors, 3 caps)
Max Malins (Bristol Bears, 3 caps)
Jonny May (Gloucester Rugby, 61 caps)
Paolo Odogwu (Wasps, uncapped)
Harry Randall (Bristol Bears, uncapped)
Dan Robson (Wasps, 7 caps)
Henry Slade (Exeter Chiefs, 34 caps)
Anthony Watson (Bath Rugby, 46 caps)
Ben Youngs (Leicester Tigers, 104 caps)
Luke Cowan-Dickie (Exeter Chiefs, 26 caps)
Tom Curry (Sale Sharks, 28 caps)
Ben Earl (Bristol Bears, 8 caps)
Ellis Genge (Leicester Tigers, 23 caps)
Jamie George (Saracens, 54 caps)
Jonny Hill (Exeter Chiefs, 3 caps)
Maro Itoje (Saracens, 43 caps)
Charlie Ewels (Bath Rugby, 17 caps)
Courtney Lawes (Northampton Saints, 85 caps)
Joe Marler (Harlequins, 72 caps)
Beno Obano (Bath Rugby, uncapped)
Will Stuart (Bath Rugby, 8 caps)
Sam Underhill (Bath Rugby, 22 caps)
Billy Vunipola (Saracens, 56 caps)
Harry Williams (Exeter Chiefs, 18 caps)
Mark Wilson (Newcastle Falcons, 19 caps)
Tom West (Wasps, 0 caps)
LIST | 5 England internationals linked with HUGE transfers
1. Anthony Watson to Harlequins
He is set to leave Bath at the end of the 2020/21 Premiership season, according to RUCK sources. The 26-year-old, who had been linked with a move to Racing 92, is instead set to join Harlequins.