Exeter Chiefs centre Henry Slade has emerged as a doubt for England's Six Nations finale in Ireland because of a lower leg problem.
The Exeter back has started every match in the tournament so far but sustained an injury in training on Monday.
A decision on his availability for Saturday's game is expected on Wednesday.
If Slade fails to recover in time, Ollie Lawrence or uncapped Paolo Odogwu are likely to take his place and Harlequins back Joe Marchant has already been called into camp as cover.