Ireland lock Devin Toner has been ruled out of the remainder of the 2019 Guinness Six Nations championship with an ankle injury.
The 32-year-old limped off during the second half of Ireland's heavy opening-round loss to England and has already had an operation to repair the problem.
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The Leinster lock is facing a two-month absence and is a doubt for the European Cup quarter-final against Ulster.
Sean O'Brien also sat out training at Murrayfield on Friday but is expected to start against Scotland on Saturday.
