Maro Itoje will make his 50th appearance for England while Captain Owen Farrell returns to the side at inside centre, Henry Slade stays at outside centre, and Marcus Smith will start at fly half.
Jonny May (left) and Tuilagi (right) will be on the wings, Freddie Steward is at full back and Ben Youngs is at scrum half.
Here’s how former players, pundits and fans have reacted on social media:
5 rugby players who pulled off insane body transformations
#1. David Pocock
The Wallabies legend started out as an skinny 78kg teen who worked day in and day out to transform himself, with his size and strength came at a cost, Pocock told Australian Story.
#2.Luther Burrell
The centre missed out on Eddie Jones’ first squad for the Six Nations Grand Slam triumph in 2016 with the Aussie labelling him “grossly overweight”.
He revealed his incredible body transformation online yesterday saying in the caption…
‘Putting a picture up like this for me was very challenging and potentially very embarrassing. It can sometimes put you in a vulnerable position…. So I seriously can’t thank everyone enough for contacting me, showing interest in my continued journey and also being kind I’m still smashing through messages, so please bare with me if I haven’t yet got back to you. •’
#3.Matt Dunning
When he was a prop for the Wallabies Matt Dunning weighed 130kg and was constantly mocked for his tubby frame.
But since retiring from rugby union the 35-year-old has lost a staggering 40kg, dropping from 25 per cent body fat to just 11 per cent in six months.
He looks amazing.
#4.Sam Underhill
#5 Vicky Fleetwood
England flanker/hooker Fleetwood was always a fitness freak, but during lockdown she has taken it to another level. She's been documenting her journey, sharing training routines and recipe ideas on her Instagram along the way.
How do you like the look of this @EnglandRugby team??! So much to talk about!! Smith finally starts at 10, Manu on the wing! Simmonds, Dombrandt and Sale boys Bevan & Raffi on the bench!!💪🏽🌹 #ENGvAUS@primevideosport
Manu Tuilagi to play on the wing for England v Australia with Marcus Smith, Owen Farrell and Henry Slade all starting. Adam Radwan drops out of the 23.
England 6-2 on the bench with Sam Simmonds and Alex Dombrandt both involved. Raffi Quirke and Bevan Rodd in line for debuts.