England boss Eddie Jones has received another major blow as Luke Cowan-Dickie joins Exeter team-mate Jack Nowell in being absent on medical grounds.
The hooker and winger will both undergo surgery on minor injuries.
Nowell now faces up to a month on the sidelines after it was confirmed that the wide-man will have to undergo surgery on torn ligaments in his toe.
“I’ve ruptured all the ligaments around my toe, which is not ideal. I’ve been strapped up for the last two weeks and have had to dig deep a little bit,” Nowell said.
“Our physios and doctors have got me in a position where I can be on the field and unfortunately I am going to have to get it fixed next week.
“If I’m perfectly honest, I haven’t trained in two weeks. I’ve loved that, but the coaches have hated it. They’ve trusted me to go out there and perform at the weekend.”
In addition, there is no place in the England squad for the Simmonds brothers, Sam and Joe, according to the Mail Online.
QUILTER CUP 2020
- Sunday 25 October 2020: England v Barbarians, KO 14:00 GMT, Twickenham Stadium (LIVE on Sky Sports Arena)
GUINNESS SIX NATIONS 2020
- Saturday 31 October 2020: Italy v England KO 16:45 GMT, Stadio Olimpico, Rome (LIVE on ITV)
ENGLAND MEN 2020 QUILTER INTERNATIONALS AS PART OF THE AUTUMN NATIONS CUP
- Saturday 14 November 2020: England v Georgia KO 15:00 GMT, Twickenham Stadium (LIVE on Amazon Prime)
- Saturday 21 November 2020: England v Ireland KO 15:00 GMT, Twickenham (LIVE on Amazon Prime and Channel 4)
- Saturday 28 November 2020: Wales v England KO 16:00 GMT, venue TBC (LIVE on Amazon Prime)
- Sunday 6 December 2020: England v TBC KO 14:00 GMT, Twickenham Stadium (LIVE on Amazon Prime)
RANKED: Which Autumn Nations Cup Team Has the Most Foreign-Born Players?
This year, 11 South Africans, 10 New Zealanders and six Aussies will take to the field during the Autumn Nations Cup despite their countries not taking part.
Find out who has the most as we rank the participants from least to most.
8. GEORGIA – 1
- Merab Sharikadze (Russia)
7. FIJI – 2
- Ben Volavola (Australia)
- Sam Matavesi (England)