Exeter ran in 10 tries to inflict a humiliating defeat on Harlequins and secure a home semi-final in their maiden Premiership play-off campaign
The Chiefs had been 17-10 up at half-time, ran riot in the second half as the Harlequins defence fell apart.
Henry Slade starred at centre, while wing Jack Nowell scored a hat-trick
Jack Nowell scored a hat-trick as Exeter Chiefs ran riot at the Stoop to book a home semi-final in Aviva Premiership Rugby against Wasps.
James Short, Nowell and Dave Ewers crossed in the first half before Danny Care responded just before half-time to narrow the deficit.
But Exeter, who will host a Wasps side in the semi-finals they beat 24-3 just a week ago, raced out of the blocks after the break with a second Short try sandwiched between two Nowell scores.
Further tries came through Will Chudley, Julian Salvi, Phil Dollman and a sublime Henry Slade, the outside centre an outlet all afternoon, while Kyle Sinckler and Winston Stanley grabbed Harlequins consolations.
MAN OF THE MATCH
Exeter Chiefs: Jack Nowell
Harlequins: 15 Mike Brown, 14 Marland Yarde, 13 Winston Stanley, 12 Jamie Roberts, 11 Ross Chisholm, 10 Nick Evans, 9 Danny Care (c), 8 Nick Easter, 7 Jack Clifford, 6 Chris Robshaw, 5 Charlie Matthews, 4 George Merrick, 3 Will Collier, 2 Dave Ward, 1 Mark Lambert
Replacements: 16 Rob Buchanan, 17 Owen Evans, 18 Kyle Sinckler, 19 Sam Twomey, 20 Mat Luamanu, 21 Karl Dickson, 22 Ben Botica, 23 Joe Marchant
Exeter: 15 Phil Dollman, 14 Jack Nowell, 13 Henry Slade, 12 Sam Hill, 11 James Short, 10 Gareth Steenson, 9 Dave Lewis, 8 Thomas Waldrom, 7 Julian Salvi, 6 Dave Ewers, 5 Damian Welch, 4 Mitch Lees, 3 Harry Williams, 2 Jack Yeandle (c), 1 Alec Hepburn
Replacements: 16 Luke Cowan-Dickie, 17 Ben Moon, 18 Carl Rimmer, 19 Geoff Parling, 20 Kai Horstmann, 21 Dave Lewis, 22 Ian Whitten, 23 Olly Woodburn
Date: Saturday, May 7
Venue: Twickenham Stoop
Kick-off: 15:30 BST (14:30 GMT)
Referee: Wayne Barnes
Assistant Referees: Paul Burton, Nigel Carrick
TMO: Sean Davey