England lock Joe Launchbury has been ruled out of the autumn internationals after having knee surgery.
The 27-year-old, who has 54 caps for his country, will be sidelined for 10 to 12 weeks.
Launchbury picked up the injury while captaining club side Wasps in their Premiership victory over Leicester on 16 September.
England play South Africa at Twickenham on 3 November, before facing New Zealand, Japan and Australia.
Wasps have also confirmed scrum-half Dan Robson will have an operation on his ankle on Friday, ruling him out for 12 weeks.