Scotland front-row Zander Fagerson appears set to miss the opening few rounds of the Six Nations after suffering a foot injury.
The Glasgow prop has been ruled out for around eight weeks following an incident in training on Thursday.
Head coach Gregor Townsend is therefore likely to go into the competition without his three best tightheads, with WP Nel also injured and Edinburgh’s Simon Berghan suspended.
They are joined on the sidelines by front-row colleague Fraser Brown, who will see a specialist after a series of head knocks this season.