Saracens have confirmed that fullback back Alex Goode will be ruled out for up to four months after having an operation on a chest injury.
The 31-year-old tore a pectoral muscle during the Premiership defeat by Northampton Saints last weekend.
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Goode, who has won 21 caps for England, captained Sarries from fly-half as the defending champions lost 27-25.
Meanwhile, 20-year-old hooker Kapeli Pifeleti will be out for around 10 weeks with a knee injury he suffered in the same match.