WEEK FOUR:
| Tonga v Uruguay Stadionul National Arcul de Triumf, Bucharest Saturday, 19 November, 2022 | Referee: Craig Evans (WRU) Assistant Referee 1: Luc Ramos (FFR) Assistant Referee 2: Anthony Woodthorpe (RFU) TMO: Sean Brickell (WRU) |
| Romania v Samoa Stadionul National Arcul de Triumf, Bucharest Saturday, 19 November, 2022 | Referee: Mathieu Raynal (FFR) Assistant Referee 1: Eoghan Cross (IRFU) Assistant Referee 2: Shota Tevzadze (GRU) TMO: Thomas Charabas (FFR) |
| England v New Zealand Twickenham, London Saturday, 19 November, 2022 | Referee: Nic Berry (RA) Assistant Referee 1: Damon Murphy (RA) Assistant Referee 2: Nika Amashukeli (GRU) TMO: Brian MacNeice (IRFU) |
| Wales v Georgia Principality Stadium, Cardiff Saturday, 19 November, 2022 | Referee: Andrea Piardi (FIR) Assistant Referee 1: Pierre Brousset (FFR) Assistant Referee 2: Gianluca Gnecchi (FIR) TMO: Brendon Pickerill (NZR) |
| Italy v South Africa Stadio Luigi Ferraris, Genova Saturday, 19 November, 2022 | Referee: Mike Adamson (SRU) Assistant Referee 1: Matthew Carley (RFU) Assistant Referee 2: Sam Grove-White (SRU) TMO: Eric Gauzins (FFR) |
| Scotland v Argentina Murrayfield, Edinburgh Saturday, 19 November, 2022 | Referee: Karl Dickson (RFU) Assistant Referee 1: Luke Pearce (RFU) Assistant Referee 2: Ian Tempest (RFU) TMO: Brett Cronan (RA) |
| Ireland v Australia Aviva Stadium, Dublin Saturday, 19 November, 2022 | Referee: Ben O’Keeffe (NZR) Assistant Referee 1: James Doleman (NZR) Assistant Referee 2: Tual Trainini (FFR) TMO: Stuart Terheege (RFU) |
| French Barbarians v Fiji Stade Pierre Mauroy, Lille Saturday, 19 November, 2022 | Referee: Chris Busby (IRFU) Assistant Referee 1: Ben Blain (SRU) Assistant Referee 2: Benoit Rousselet (FFR) TMO: Ben Whitehouse (WRU) |
| France v Japan Stadium de Toulouse, Toulouse Sunday, 20 November, 2022 | Referee: Andrew Brace (IRFU) Assistant Referee 1: Frank Murphy (IRFU) Assistant Referee 2: Christophe Ridley (RFU) TMO: Tom Foley (RFU) |