Leigh Halfpenny has been ruled out of Wales' opening Six Nations game away to France in Paris on Friday, 1 February.
The 30-year-old British and Irish Lions back has not played since suffering concussion in the win over Australia on 10 November.
Scrum-half Gareth Davies and centre Scott Williams are also major injury doubts to face Les Bleus.
Scarlets lock Jake Ball is the only player in the 39-man squad released back to his region this weekend.
